This could actually be a reaction to the prednisone and you should take some Benadryl for the hives and this will help to stop the reaction. It can be a reaction as far as the pain as well and if so this could last for up to 72 hours after the last dosage so if this still continues to be a problem or gets worse after the Benadryl and the stopping of the Prednisone than you do need to let them know so they can perform further evaluation.
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