AZ,
He sounds like he's feeling terrible. Unfortunately, the Casodex could be making his edema worse. If he has gained all this weight in a very short time, I think he really should call someone, either his Urologist or the doctor who prescribed the HCTZ.
There are much stronger medications for edema than HCTZ that can be prescribed. Also, his Urologist really should be informed of the edema; there may be some other medication he can prescribe as well. Incidentally, Lupron can cause edema as well.
Finally, if he hasn't had an echocardiogram of his heart in the last year or so, I'd recommend this too. You just want to make sure that all this swelling is not from heart failure.
See this:
http://www.rxlist.com/cgi/generic/leuprolide_ad.htm
Regards....
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