Sorry -- we seem to be playing email tag instead of phone tag! Thank you for the update.
Enlargement of the heart results from (a) thickening of the heart muscle, from (b) dilating of the heart chambers, or from (c) a combination of both. Stage I, of course, is the earliest mildest of the stages.
The heart muscle ('myocardium') can be thickened by high blood pressure & by stricture of any of the 4 heart valves. Heart muscle thickening, 'hypertrophy', is less noticeable on xrays than chamber dilatation. Stage I (your sister) is mild, so hypertrophy is a possibility.
The chambers can become dilated by back-leakage in a valve or by weakening of the myocardium to the point that it can no longer pump out enough blood. Dilated chambers produce the more pronounced cases of cardiac enlargement (maybe not your sister).
The valve problems can be a birth defect, can be caused by rheumatic fever, or can occur as calcium deposits which accumulate w/ age ('calcific aortic stenosis').
The heart muscle can be weakened directly (without involvement of valves) by alcohol ('alcohol mycardiomyopathy') & by infections of the heart muscle ('myocarditis').
At your sister's age, many causes are ruled out (congenital heart valve disease, rheumatic fever, alcoholism). The most common cause for your sister's age-group is actually high blood pressure ('hypertension'), which puts a persistent strain on th heart muscle over a long period of time, producing a thickening of the heart muscle & then later gradual weakening of the heart muscle w/ dilatation. If she has a heart murmur, she might have 'calcific aortic stenosis', as this is commonly the cause in her age group.
It is a known fact that some cases are due to infection of the heart muscle by several types of virus, known as viral myocarditis. Rocky Moutain Spotted Fever is not caused by a virus; however its cause, a germ known as Rickettsia, is a germ that shares features of both viruses & bacteria. It is quite possible that RMSF was involved in your sister's heart problem -- provided that hypertension & valve trouble are not involved. By now the rickettsia germ is no longer in her body, but her enlarged heart could be an after-effect.
There are medications to improve her heart by reducing load on the heart & to a lesser degree by strengthening the myocardium.
Hope this is helpful & sorry about the delays. Feel free to add any questions or to share any other details of her illness.