Hello Tiff,
The lymphadenopathy in HIV patients will need evaluation for the causes specifically infective causes (tuberculosis, toxoplasmosis) and malignant causes. If no cause is ascertained, it is called persistent generalized lymphadenopathy. The CD4 count and viral load estimation also play crucial role in management, and so do the size and number of groups.
Here is an excellent resource where you can read about management of lymph node enlargement in HIV:
http://www.aidsetc.org/aidsetc?page=cm-410_lymph
Please feel free, if you have further questions.
Dr. Arun
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