Modern serologic techniques, such as enzyme-linked immunosorbent assay (ELISA), have been used to detect IgG, IgM, IgA antibodies to both whole B pertussis cells and certain isolated components. In accordance with other serologic methods, seroconversion could be observed only 2 to 4 weeks after the onset of the disease. The detection of specific IgA and IgM antibodies, however, is indicative of recent infection and is useful for the differential diagnosis of pertussiform syndromes of longer duration. Detection of IgG antibody indicates past infection.