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PREGNANCY

Sent to Health Experts July 11 02:14 PM

I have just found out that I am 11 weeks and 5 days pregnant. I have a 17 yr old and a 3 yr old I am 39 yrs of age 5'2" and weigh 250lbs. I am taking high blood pressure meds and I had a PE approximately 2 yrs ago so have been told I will need to take Heparin thru out my pregnancy. I AM FRIGHTENED!! I am highly concerned with my health. I have been sick since June 10th with Bronchitis and was admitted on 6/12 for low oxygen levels rapid heart rate and pulse rate. I have had numerous meds which I went over with my OB/GYN 2 which fall under the B category while pregnant and I had 2 chest x-rays (June 12 and the other June 13th) I also had a contrast CT on 6/12th of my chest to rule out another possible PE all of this was done without my having any pregnancy concerns as I had recvd my last menstruation May 24th. I am so seriously concerned with my HEALTH I have not been 100% since. I continue to have coughing and have used my nebulizer at home at least once a day since the 10th of June. Again I want to know how HIGH RISK AM I if I proceed with this pregnancy, I do not mean to sound selfish but I in no way can imagine leaving my 3 yr old without his MOMMY and quite frankly I am WORRIED about my health. I need FRANK DIRECT TRUTHFUL well informed information. Thank you

Customer (name blocked for privacy)
Answer
July 11 4:46 PM (2 hours and 32 minutes and 25 seconds later)
         
REPLIEDCheck Mark

You are at high risk for miscarrying your fetus not to mention the risk to your own health (B/P meds, nebulizer chemicals, morbid obesity, hypoxia).

Category B Medications are considered by the FDA to be safe in pregnancy.

Your pregnancy is high-risk due to maternal factors e.g. your age (older than age 35); weight (pre-pregnancy obesity); height; hypertension ("taking high blood pressure meds"); pre-existing chronic illness (Bronchitis); and PE approximately 2 yrs ago "so have been told I will need to take Heparin thru out my pregnancy". Your pregnancy is high-risk due to a fetal factor of the fetus' exposure to Heparin. A pregnancy is considered high-risk when prenatal tests indicate that the baby has a serious health problem (for example, a heart defect possibly due to Heparin or the chemicals from the nebulizer treatments). You will need special tests, and possibly medication, to carry the baby safely through to delivery. You will need a perinatologist. A perinatologist is a medical doctor (obstetrician) who specializes in the care of women who are at high risk for having problems during pregnancy. Perinatologists care for women who have pre-existing medical problems as well as women who develop complications during pregnancy. You will need blood tests to check the levels of your medication, amniocentesis, serial ultrasound examinations, and fetal monitoring.





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Reply
July 11 5:07 PM (21 minutes and 2 seconds later)
         
Reply to Dr. Hanson's Post: So is it safe to say that I was misinformed when I was told that Heparin during pregnancy is to be considered safe? The chemicals I use in the nebulizer are albuterol and ipratropium bromide combined do these pose a threat to the baby and if yes such as what? I am not sure if you can answer my next question but would it be fair to say given my age weight and medical condition I should NOT continue with this pregnancy. I ask because come Friday I will be at 12 weeks and I know that if my husband and I were to make a choice it would have to happen NOW and yes I am talking with regards to us choosing to abort the baby. I cannot emphasize enough how long and hard we have tried to come to some well informed correct decision the one thing that we both come back to is HOW MUCH DANGER AM I IN IF I CONTINUE WITH THIS PREGNANCY and well I am in no way prepared to knowingly choose to leave my 3 yr old motherless. I am as i said 39 my husband is 42, we have 2 boys and had it not been for the PE that involved my not being able to continue with my birth control we would not have elected to be at this point and YES my husband has since scheduled to have surgery to prevent this again but of course that does not change where we are now. THANK YOU
Answer
July 11 6:14 PM (1 hour and 6 minutes and 36 seconds later)
         
REPLIEDCheck Mark

ALBUTEROL: Pregnancy: Teratogenic Effects: Pregnancy Category C. Albuterol sulfate has been shown to be teratogenic in mice . . . .cleft palate formation. A reproduction study in Stride Dutch rabbits revealed cranioschisis in 7 of 19 fetuses (37%) when albuterol sulfate was administered orally . . . In an inhalation reproduction study in New Zealand white rabbits, albuterol sulfate/HFA-134a formulation exhibited enlargement of the frontal portion of the fetal fontanelles. . . .A study in which pregnant rats were dosed with radiolabeled albuterol sulfate demonstrated that drug-related material is transferred from the maternal circulation to the fetus. There are no adequate and well-controlled studies of VENTOLIN HFA or albuterol sulfate in pregnant women. VENTOLIN HFA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. During worldwide marketing experience, various congenital anomalies, including cleft palate and limb defects, have been reported in the offspring of patients being treated with albuterol. Some of the mothers were taking multiple medications during their pregnancies. . . .Use in Labor and Delivery: Because of the potential for beta-agonist interference with uterine contractility, use of VENTOLIN HFA for relief of bronchospasm during labor should be restricted to those patients in whom the benefits clearly outweigh the risk. Tocolysis: Albuterol has not been approved for the management of preterm labor. The benefit:risk ratio when albuterol is administered for tocolysis has not been established. Serious adverse reactions, including maternal pulmonary edema, have been reported during or following treatment of premature labor with beta2-agonists, including albuterol.


ATROVENT Inhalation Aerosol Category B should be used during pregnancy only if clearly needed.Pregnancy. . . . . .no adequate or well controlled studies have been
conducted in pregnant women. Because animal reproduction studies are not always
predictive of human response, ATROVENT Inhalation Aerosol should be used during
pregnancy only if clearly needed.


ANTI-COAGULANTS: Prenatal exposure to oral anticoagulants [warfarin/coumadin] during pregnancy may result in defective fetal development or life-threatening hemorrhage. Fetal exposure during the first eight weeks of pregnancy may cause abnormal development of the facial structures, hypoplastic digits, strippled epiphyses, and mental retardation. Midtrimester exposure may result in optic atrophy, faulty brain growth, and developmental retardation. Third-trimester exposure may produce fetal anticoagulation, predisposing the infant to life-threatening hemorrhage in the perinatal period. Anticoagulation with heparin sodium does not provide a clearly safe alternative, since this therapy has been associated with excessive fetal loss. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7359739&dopt=Abstract

Heparin: Pregnancy Category C. Animal reproduction studies have not been conducted with heparin sodium. It is also not known whether heparin sodium can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

Nonteratogenic Effects: Heparin sodium does not cross the placental barrier.

HEPARIN Sodium
Mnfr. WYETH-AYERST
Not FDA approved for pregnancy, labor, delivery or lactation.PDR pg. 3376
Anticoagulant therapy and prophylaxis for venus thrombosis. It is not known whether Heparin Sodium can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Animal and human reproduction studies have not been conducted with Heparin Sodium.
For more information from the manufacturer call or write:
Wyatt-Ayerst Pharmaceuticals
Division of American Home Products Corporation
P.O. Box 8299
Philadelphia, PA 19101
Tel: (610) 688-4400
Direct inquiries to: (800) 934-5556

http://www.aimsusa.org/ObstetricDrugs-NotApproved.htm


Risk assessment is an important part of prenatal care. You and your husband's autonomous decision should be based upon factual information. Both you and your husband are entitled to professional prenatal counseling. Most insurance plans cover the cost of prenatal counseling for "at-risk" pregnancies. Most obstetrical practices have genetic and prenatal counselors who provide information and assist the mother and father with risk assessment. This is your right and your duty to your two children and also to the fetus. Medical ethics is based upon the principles of beneficence, non-maleficence, and autonomy. Beneficence which means a physician should act in the best interest of his patient. Non-maleficence means a physician should "first, do no harm". Autonomy means that the patient has the right to refuse or choose their treatment. With respect to first trimester abortion, legally you are entitled to terminate your pregnancy due to risk to your life and well-being. You and your husband will have to live with your decision for the rest of your lives. It is a decision nobody can make for you. You must consider the consequences of your autonomous informed decision BEFORE you decide.




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Reply
July 11 9:02 PM (2 hours and 48 minutes and 13 seconds later)
         
Reply to Dr. Hanson's Post: First let me say Thank you for all of your detailed information and truthfully you helped me be sure of the things I was already very aware to have HIGH concerns with. I am to be at the doctors office tomorrow and will be direct with them and pray that I am given the appropriate answers and guidance with this. When I was seen last week my concerns were all expressed and I gave a written list of al my meds and was pretty much left to be believe things were okay but my own insecurities and how we say gut feelings still have had me on edge all day every day and I am quite greatful to you and your direct information. I would love to be able to let you know how it goes but am not sure if that is acceptable here and of course am not sure how I could contact you. I can say that I will be more confident and staright forward as to my need to be well informed Thanks to you.
Answer
July 11 10:18 PM (1 hour and 16 minutes and 20 seconds later)
         
ACCEPTEDCheck Mark

Always demand that your physician or any other healthcare provider explain "ALL" aspects of your medical care so that you do not have to "look back" and wonder "if I'd only have known . . . . " A physician should not be "too busy" to explain his rationale for his medical decisions to his patient. If you find a physician who acts "too busy" or relegates the responsibility of patient education to another staff member e.g. a nurse or clerk then I recommend that you get busy and find another physician.

Please contact me anytime at this justanswer! site by asking for Dr. Hanson or "Private Message" me using the PM feature on this site.



Edited by DrHanson on July 11 2006 at 10:24 PM



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