Hi lianne--good to hear from you again; thx for quick reply!
Here are the Answers:
1. Does the current case of acne typically get worse before it gets better?
A: YES: In my 12+ yrs RXing it, I'd say 60% of pts get worse, before getting better; PART of the reason is just natural progression of the dz (Acne vulgaris), esp. since it takes minimum 7-10 days for the drug to get to EFFECTIVE concentration in your blood; the rest is due to a 'drawing out' effect that it has on your skin pores (kind of like cleansing your bowels w/ a cathartic).
2. How long before seeing any improvements?
A: Typically, about 3-4 weeks (but can RANGE from 2 wks, up to 8 wks)
3. What typical side effects are there?
A: most common are: dry mouth & nose; cracking or inflamed lips; (I got both of these, when I took it about 17 yrs ago); dry eyes (this is why you shouldn't wear contacts); red eyes; general dry skin; vague muscle aches (episodic). These are the fairly common side effects. There are some more serious/dangerous side effects, which are included in this public link:
http://www.fda.gov/cder/drug/InfoSheets/patient/IsotretinoinPT.htm
(Don't be too scared by all that's listed here--most of the serious effects are quite uncommon; anywhere from <1% to about 5-6%). In general, I advise NOT to stay on it too long--perhaps about 5-7 months (at most), to get your face all CLEANED up (and pretty Images available only to Customers.
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Info given herein is general health info, and NOT a substitute for needed M.D. attn