The expiry date for many tablets is about 2 to 3 years, although some is longer. The box or bottle should have the actual recommended expiry date on it. If it doesnt, then you will have to play safe and not use the Bactrim. Most medication will become less effective after it expires but some will deteriorate and the byproducts will then cause an allergy or side effect.
Because tablets are tested very thouroughly then the expiry date will be the last date at which the FDA recommend administration. After this date, there will be no evidence of safety or efficiacy tests.
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