Good Evening,
Ortho Evra as you know contains estrogen, actually a lot of it. I believe its about 60% more in the patch than in the actual pill. Estrogen affects the joints of the body by softening the ligaments, most particularly the ACL. It would be okay but, when ligaments are a little too soft, they are too stretchy and can cause injury to the joint from the lack of protection. The slightest wrong move at the wrong time may have injured your knee a bit. Usually, rest is the best way to heal an injury like this. Although, if the pain still persists after you keep of the joint or have any other symptoms like loss of range of motion, you will want to go to the doctor to get an MRI to check for any tears.
As far as the nodules you are feeling, what do they look like to you? Did they show up at the same time as the pain?
Shyla RN
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